Aiyuk's knee injury puts his Week 1 status in question, creating a window for Moore and others to seize targets. When healthy, Aiyuk remains SF’s top WR; his absence could temporarily elevate Moore/J Jennings/Robinson, but the long-term plan centers on Aiyuk reclaiming the primary role as SF’s offense evolves under Shanahan.

Aiyuk’s health looms in SF’s WR mix, and Moore’s arrival could shift roles. If Aiyuk returns to full form, he remains the top outside option, while Moore and the others compete for the ancillary targets. Aiyuk’s performance directly influences the fantasy floor for SF’s passing game in Weeks 1-4, making his status a critical anchor for the offense’s overall fantasy output.

Aiyuk’s ACL rehab shapes SF’s week-to-week targets; his return timeline remains pivotal for SF’s WR plan. If he misses time, the rest of SF’s corps—Moore, Jennings, Watkins, Cowing—will shoulder more of the air-game load, while Aiyuk’s presence will eventually anchor the target tree and restore SF’s offensive balance.

Aiyuk’s knee injury opens a window for Skyy Moore to emerge early as SF’s top target, temporarily thinning SF’s WR room. His status remains pivotal for SF’s Week 1 plans, and his absence could magnify Moore’s initial impact while Jennings recovers.

Aiyuk, sidelined by a torn ACL/MCL in his right knee, is the headline absence for Week 1. His recovery timeline targets Week 6, tightening SF’s early receiving corps. The injury compounds the challenge in a room already contending with Robinson’s absence, elevating Pearsall and Jennings as primary Week 1 beneficiaries.