Aiyuk's return window from IR is discussed; season-long and playoff implications hinge on when he is activated, with potential long-term impact if he misses most or all of the season.

Aiyuk’s fantasy value hinges on quick throws and the offense’s ability to create separation. With Jones’ fast releases and SF’s scheme, he can remain a target-rich option, especially in high-percentage passing scenarios designed to support the QB transition.

Aiyuk’s value is contingent on his health. If active, he remains a key target, especially in a Purdy-less offense, but his production could dip if defenses affect the schedule with other weapons sidelined.

Aiyuk is listed as out, reducing SF’s top-tier WR threat and narrowing the offense’s ceiling in a tough matchup.

Aiyuk remains a focal point for SF’s passing game despite injuries, with potential for high-target weeks if Purdy adapts. Aiyuk’s route running and red-zone involvement keep him in the fantasy spotlight as SF navigates a tough TNF slate.